[Alkaline phosphatase level and bone density in Scheuermann's disease and in adolescent idiopathic scoliosis].

Abstract

Authors made a comparison between 167 suffers from Scheuermann's disease (SD), 70 adolescence idiopathic scoliosis (AIS) and 132 age, sex, height, weight, pubertal developmental stages (Tanner stages) matched controls. The height percentile in 130 cases was also determined. The bone mineral density (BMD) was measured by pQCT on the non dominate sided radial bone. The alkaline phosphatase (AP) level increased at the beginning of puberty and in the puberty in SD. In SD the trabecular Z-score of BMD was significantly decreased in Tanner stage 1 to 4 in both boys and girls. It was not found any significance difference, however, in Tanner stage 5, while in AIS girl no significance decrease of BMD was found. In SD good correlation could be demonstrated between increase in AP and decrease in trabecular Z score r = 0.2, while did not correlate with height percentile. The AP level's increase, and radiomorphometric data of SD severity (intervertebral space narrowing and antero-posterior diameter increase of vertebral body) shows a significant correlation with decreased trabecular Z-score in the period of prepuberty.

• Authors: S Viola, F Péter, I György, L Szécsényi N
• Journal: Orvosi hetilap (Orv Hetil) Vol. 141 Issue 17 Pg. 905-9 (Apr 23 2000) ISSN: 0030-6002 [Print] Hungary
• Vernacular Title: Az alkalikus foszfatáz-szint és csontsúrúség Scheuermann-kórban és adolescens idiopathiás scoliosisban.
• PMID: 10827471 (Publication Type: Journal Article)

Chemical References

• Alkaline Phosphatase

Topics

• Adolescent
• Alkaline Phosphatase (blood)
• Body Height
• Bone Density
• Bone Diseases, Metabolic (enzymology, etiology)
• Case-Control Studies
• Female
• Humans
• Male
• Scheuermann Disease (complications, diagnostic imaging, enzymology, metabolism)
• Scoliosis (complications, diagnostic imaging, enzymology, metabolism)
• Tomography, X-Ray Computed