Ion channels and epilepsy in man and mouse.

Abstract

Inherited disorders of voltage-gated ion channels are a recently recognized etiology of epilepsy in the developing and mature central nervous system. Two human epilepsy syndromes, benign familial neonatal convulsions and generalized epilepsy with febrile seizures plus, represent K+ and Na+ channelopathies, and other newly defined syndromes have now been mapped to chromosomal regions that are rich in ion channel genes. Experimental mouse models promise a resolution of their intriguing pathophysiology, which includes a diverse array of cellular phenotypes consistent with the differential contributions of individual channels to excitability in neural networks.

• Authors: O K Steinlein, J L Noebels
• Journal: Current opinion in genetics & development (Curr Opin Genet Dev) Vol. 10 Issue 3 Pg. 286-91 (Jun 2000) ISSN: 0959-437X [Print] England
• PMID: 10826987 (Publication Type: Journal Article, Review)

Chemical References

• Calcium Channels
• Ion Channels
• Potassium Channels
• Sodium Channels

Topics

• Animals
• Brain (physiopathology)
• Calcium Channels (physiology)
• Epilepsy (genetics, physiopathology)
• Humans
• Ion Channels (genetics, physiology)
• Mice
• Potassium Channels (genetics)
• Sodium Channels (genetics)