Protection of cattle against bovine leukemia virus (BLV) infection could be attained by DNA vaccination.

Abstract	The bovine leukemia virus (BLV) envelope gene encoding extracellular glycoprotein gp51 and transmembrane glycoprotein gp30 was cloned into a vehicle expression vector under the human cytomegalovirus (CMV) intermediate early promoter. The intramuscular injection of this plasmid vector generated a cellular immune response. Seven out of ten cows vaccinated with the DNA construct resisted a drastic challenge (500 BLV-infected lymphocytes as an infectious dose).
Authors	A Brillowska, S Dabrowski, J Rułka, P Kubiś, E Buzała, J Kur
Journal	Acta biochimica Polonica (Acta Biochim Pol) Vol. 46 Issue 4 Pg. 971-6 ( 1999) ISSN: 0001-527X [Print] Poland
PMID	10824867 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Antibodies, Viral DNA Primers Vaccines, DNA Viral Vaccines
Topics	Animals Antibodies, Viral (biosynthesis) Base Sequence Cattle DNA Primers (genetics) Enzootic Bovine Leukosis (immunology, prevention & control) Genes, env Humans Immunity, Cellular Leukemia Virus, Bovine (genetics, immunology) Plasmids (genetics) Vaccines, DNA (administration & dosage, pharmacology) Viral Vaccines (administration & dosage, pharmacology)

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