The efficacy of biochemical markers in patients with ossification of posterior longitudinal ligament of the spine.

Abstract

STUDY DESIGN:

Serum levels of carboxyterminal propeptide of type I collagen (PICP), osteocalcin (OC), carboxyterminal telopeptide of type I collagen (ICTP) and urinary levels of pyridinoline (Pyr) and deoxypyridinoline (Dpyr) were measured in patients with ossification of posterior longitudinal ligament of the spine (OPLL) and age-matched control subjects.

OBJECTIVES:

To evaluate the efficacy of these biochemical markers of the patients with OPLL.

SETTING:

Department of Orthopedic Surgery, Hamamatsu University School of Medicine, Hamamatsu, Japan.

METHODS:

Spot urine and blood samples were obtained from 20 healthy males aged 45 - 78 (mean+/-SD; 63. 0+/-11.5) and 22 male patients with OPLL aged 46 - 77 (mean+/-SD; 59. 9+/-8.8), and serum levels of PICP, OC, ICTP and urinary levels of Pyr and Dpyr were measured.

RESULTS:

There were no significant difference in age, serum PICP, OC, ICTP, urinary Pyr and Dpyr levels between OPLL and control group.

CONCLUSION:

Neither bone formation nor bone resorption was accelerated in the patients with OPLL.

• Authors: C Ishihara, K Kushida, M Takahashi, T Ohishi, H Murata, A Nagano, S Goto
• Journal: Spinal cord (Spinal Cord) Vol. 38 Issue 4 Pg. 211-3 (Apr 2000) ISSN: 1362-4393 [Print] England
• PMID: 10822390 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)

Chemical References

• Amino Acids
• Biomarkers
• Collagen Type I
• Peptide Fragments
• Peptides
• Procollagen
• collagen type I trimeric cross-linked peptide
• procollagen type I carboxy terminal peptide
• Osteocalcin
• pyridinoline
• deoxypyridinoline
• Collagen

Topics

• Aged
• Amino Acids (urine)
• Biomarkers (blood, urine)
• Collagen (blood)
• Collagen Type I
• Disease Progression
• Humans
• Male
• Middle Aged
• Ossification of Posterior Longitudinal Ligament (blood, urine)
• Osteocalcin (blood)
• Peptide Fragments (blood)
• Peptides (blood)
• Predictive Value of Tests
• Procollagen (blood)
• Reference Values