Abstract | AIMS/HYPOTHESIS: METHODS: RESULTS: In all results we compared patient and control subfractions. Mean fasting plasma glucose was 8.9 +/- 2.0 mmol/l in patients vs 5.1 +/- 0.4 mmol/l in control subjects (p < 0.001); patient HbA1c was 7.6 +/- 1.4%. Patient total lipid standardised for apo B was higher than controls in subfractions A, B and C; A, 201 vs 60; B, 191 vs 40; C, 63 vs 21; D, 29 vs 34 micromol lipid per mg apo B (p < 0.05). Preformed peroxides were higher in all patient subfractions compared with controls: A, 340 vs 48; B, 346 vs 42; C, 262 vs 28; D, 54 vs 16 nmol per mg apo B (p < 0.001). Patient subfractions A and D were more susceptible to in vitro oxidation. Monounsaturated fatty acids were lower in patients subfractions, 35.2 vs 36.7; B, 35.1 vs 38.7; C, 34.4 vs 36.5; D, 33.0 vs 35.5 as per cent total (p < 0.05). CONCLUSIONS/INTERPRETATION: These results indicate abnormalities in very low density lipoprotein subfraction composition and oxidation profile in Type II diabetic subjects, which are characteristic of more atherogenic particles and that may contribute to the development of cardiovascular disease in these patients.
|
Authors | J McEneny, M J O'Kane, K W Moles, C McMaster, D McMaster, C Mercer, E R Trimble, I S Young |
Journal | Diabetologia
(Diabetologia)
Vol. 43
Issue 4
Pg. 485-93
(Apr 2000)
ISSN: 0012-186X [Print] Germany |
PMID | 10819243
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Apolipoproteins B
- Blood Glucose
- Fatty Acids
- Lipids
- Lipoproteins, VLDL
- Hydrogen Peroxide
|
Topics |
- Apolipoproteins B
(blood)
- Blood Glucose
(metabolism)
- Cardiovascular Diseases
(etiology)
- Diabetes Mellitus, Type 2
(blood, complications)
- Fatty Acids
(analysis)
- Female
- Humans
- Hydrogen Peroxide
(blood)
- Lipid Peroxidation
- Lipids
(analysis, blood)
- Lipoproteins, VLDL
(blood, chemistry)
- Male
- Middle Aged
|