Abstract | OBJECTIVE: The synovium of patients with rheumatoid arthritis (RA) is characterized by massive cell proliferation, neoangiogenesis, and apoptosis. The nature of potential repressors/inducers of these phenomena is still largely unknown. We investigate if nitric oxide (NO) and nerve growth factor ( NGF) can be considered potential mediators in these phenomena in RA. METHODS: RESULTS: Inducible NOS (iNOS) immunoreactivity and NADPH-diaphorase positivity were found in synoviocytes, fibroblast-like synoviocytes, fibroblasts, and inflammatory cells in the rheumatoid synovium. In the same areas and in the same cell types, although not in the same cells, we also found positivity for the NGF high affinity receptor trkA. CONCLUSION: We suggest that all elements involved in the transduction pathway that is activated by NGF and that proceeds through NO and tumor suppressor p53 are present in the synovium during RA, controlling cell cycle arrest, cell differentiation, and apoptosis.
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Authors | M Pozza, M Guerra, E Manzini, L Calza |
Journal | The Journal of rheumatology
(J Rheumatol)
Vol. 27
Issue 5
Pg. 1121-7
(May 2000)
ISSN: 0315-162X [Print] Canada |
PMID | 10813276
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Tumor Suppressor Protein p53
- Nitric Oxide
- Nerve Growth Factor
- Receptor, trkA
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Topics |
- Arthritis, Rheumatoid
(metabolism)
- Disease Progression
- Humans
- Immunohistochemistry
- Nerve Growth Factor
(metabolism)
- Nitric Oxide
(analysis)
- Receptor, trkA
(analysis)
- Signal Transduction
- Synovial Membrane
(chemistry, enzymology, innervation, metabolism)
- Tumor Suppressor Protein p53
(metabolism)
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