The urokinase-type plasminogen activator system in resected non-small-cell lung cancer. Rotterdam Oncology Thoracic Study Group.

Urokinase-type plasminogen activator (uPA), its receptor (uPAR) and plasminogen activator inhibitors (PAI-1 and PAI-2), all play important roles in tumour invasion and metastasis. The tumour levels of the components of the urokinase-type plasminogen activator system (uPA-system) may help to identify individuals with a poor prognosis in postoperative non-small-cell lung cancer (NSCLC) patients.
The levels of uPA, uPAR PAI-1 and PAI-2 were measured by enzyme-linked immunosorbent assay (ELISA) in triton-extracts, prepared from 88 NSCLC tissues (stage I-IIIa) and 74 normal lung tissues from the same patients.
The expression levels of uPA, uPAR, PAI-1 and PAI-2 were significantly higher in tumour tissues as compared to their normal equivalents (all, P < 0.0001). Significant relations were found between gender and uPA (P = 0.04) or uPAR (P < 0.001), and between PAI-2 and pathological stage (P = 0.03). For none of the studied factors of the uPA-system a significant relation with survival was found, neither in all patients, nor in the subgroups of patients with squamous-cell lung carcinoma or adenocarcinoma.
The expression levels of the components of the uPA-system were higher in NSCLC tissue as compared to normal lung tissue, but there were no significant relationships between their levels and survival.
AuthorsM Salden, T A Splinter, H A Peters, M P Look, M Timmermans, J P van Meerbeeck, J A Foekens
JournalAnnals of oncology : official journal of the European Society for Medical Oncology / ESMO (Ann Oncol) Vol. 11 Issue 3 Pg. 327-32 (Mar 2000) ISSN: 0923-7534 [Print] NETHERLANDS
PMID10811500 (Publication Type: Journal Article)
Chemical References
  • PLAUR protein, human
  • Plasminogen Inactivators
  • Receptors, Cell Surface
  • Receptors, Urokinase Plasminogen Activator
  • Plasminogen Activators
  • Carcinoma, Non-Small-Cell Lung (chemistry)
  • Female
  • Humans
  • Immunohistochemistry
  • In Situ Hybridization
  • Lung Neoplasms (chemistry)
  • Male
  • Neoplasm Invasiveness
  • Neoplasm Staging
  • Plasminogen Activators (analysis)
  • Plasminogen Inactivators (analysis)
  • Prognosis
  • Receptors, Cell Surface (analysis)
  • Receptors, Urokinase Plasminogen Activator
  • Retrospective Studies
  • Sex Factors
  • Survival Analysis

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