Abstract | OBJECTIVE: DESIGN: Randomised, double blind, placebo controlled trial. SETTING: 26 Danish general practices. PATIENTS: MAIN OUTCOME MEASURES:
Pain score and illness score as well as measurement of CRP and ESR values after initiation of treatment. RESULTS:
Penicillin V led to a better recovery than did placebo. The difference was statistically significant 3 days after the initiation of treatment with regard to pain reduction, whereas no significant difference was found with regard to the reduction in the sense of illness. At the end of the study, significantly more patients in the penicillin group were completely free of pain compared to the placebo group. This difference was only found in patients with an initial pain score of more than three. The cure rate was 71% in the penicillin group and 37% in the placebo group. Significantly more patients achieved normal CRP values when treated with penicillin (88%) as opposed to placebo (75%). CONCLUSION:
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Authors | J G Hansen, H Schmidt, P Grinsted |
Journal | Scandinavian journal of primary health care
(Scand J Prim Health Care)
Vol. 18
Issue 1
Pg. 44-7
(Mar 2000)
ISSN: 0281-3432 [Print] United States |
PMID | 10811043
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Placebos
- C-Reactive Protein
- Penicillin V
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Topics |
- Acute Disease
- Adolescent
- Adult
- Blood Sedimentation
- C-Reactive Protein
(metabolism)
- Denmark
- Double-Blind Method
- Family Practice
(methods)
- Female
- Humans
- Male
- Maxillary Sinusitis
(drug therapy)
- Middle Aged
- Penicillin V
(adverse effects, therapeutic use)
- Placebos
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