[An evaluation of the effect of 2,4-dichlorophenoxyacetic acid derivatives on humoral and cellular immunities].

Abstract

A single oral administration of phenoxy herbicides, viz. 2,4-dichlorophenoxyacetic acid (2,4-D), amino salt, sodium salt, diethylene glycol, iso-octyl and octyl ethers in a dose of LD16, was found to produce a pronounced suppressive effect on humoral immunity on day 5. The 2,4-D derivatives under study, administered in the same dose, stimulated the manifestations of delayed-type hypersensitivity in mice immunized with sheep red blood cells. The effect of the inhibition of antibody formation to thymus-dependent antigen ranged in the order of the increase in the toxicity of substances: amino salt, diethylene glycol ether, 2,4-D, sodium salt, iso-octyl and octyl ethers. On the contrary, the intensity of delayed-type hypersensitivity was more pronounced with regard to substances having greater toxicity.

• Authors: E A Imel'baeva, S N Teplova, F Kh Kamilov
• Journal: Zhurnal mikrobiologii, epidemiologii i immunobiologii (Zh Mikrobiol Epidemiol Immunobiol) 2000 Mar-Apr Issue 2 Pg. 60-3 ISSN: 0372-9311 [Print] Russia (Federation)
• Vernacular Title: Otsenka vliianiia proizvodnykh 2,4-dikhlorfenoksiuksusnoĭ kisloty na gumoral'noe i kletochnoe zveno immuniteta.
• PMID: 10808577 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Herbicides
• 2,4-Dichlorophenoxyacetic Acid

Topics

• 2,4-Dichlorophenoxyacetic Acid (analogs & derivatives, pharmacology)
• Animals
• Antibody Formation (drug effects)
• Herbicides (pharmacology)
• Hypersensitivity, Delayed (etiology, immunology)
• Immunity, Cellular (drug effects)
• Immunization (methods)
• Male
• Mice