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Calpain-3 gene expression is decreased during experimental cancer cachexia.

Abstract
The Yoshida AH-130 rat ascites hepatoma is a model system for studying the mechanisms involved in the protein hypercatabolism associated with cancer cachexia. The present study was aimed at investigating if the calpain-3 gene expression in skeletal muscle was affected by tumor growth. The results presented clearly show that calpain-3 gene expression is considerably reduced in experimental cancer cachexia, while there is a reciprocal change in the expression of the ubiquitin-dependent proteolytic system and in the ubiquitous m-calpain. The results, observed during cancer cachexia, suggest a potential counterregulatory role of calpain-3 in muscle proteolysis.
AuthorsS Busquets, C García-Martínez, B Alvarez, N Carbó, F J López-Soriano, J M Argilés
JournalBiochimica et biophysica acta (Biochim Biophys Acta) Vol. 1475 Issue 1 Pg. 5-9 (Jun 01 2000) ISSN: 0006-3002 [Print] Netherlands
PMID10806331 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • DNA Probes
  • Muscle Proteins
  • RNA
  • Calpain
Topics
  • Animals
  • Cachexia (enzymology, etiology)
  • Calpain (genetics, metabolism)
  • DNA Probes
  • Down-Regulation
  • Gene Expression Regulation, Enzymologic
  • Male
  • Muscle Proteins (genetics, metabolism)
  • Muscle, Skeletal (enzymology)
  • Neoplasms, Experimental (complications)
  • RNA (isolation & purification)
  • Rats
  • Rats, Wistar

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