Abstract | BACKGROUND: METHODS AND RESULTS: Fifty-four AMI patients undergoing primary PTCA were randomized to intracoronary adenosine or saline. The 2 groups were similar for age, sex, and infarct location. Adenosine administration was feasible and well tolerated. PTCA was successful in all patients and resulted in TIMI 3 flow in all patients given adenosine and in 19 given saline (P<0.05). The no-reflow phenomenon occurred in 1 adenosine patient and in 7 saline patients (P=0.02). Creatine kinase was lower in the adenosine group, and a Q-wave MI developed in 16 adenosine patients and in 23 saline patients (P=0.04). Sixty-four percent of dyssynergic segments improved in the adenosine group and 36% in the saline group (P=0. 001). Function worsened in 2% of dysynergic segments in the adenosine group and in 20% in the saline group (P=0.0001). Adverse cardiac events occurred in 5 patients in the adenosine group and in 13 patients in the saline group (P=0.03). CONCLUSIONS:
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Authors | M Marzilli, E Orsini, P Marraccini, R Testa |
Journal | Circulation
(Circulation)
Vol. 101
Issue 18
Pg. 2154-9
(May 09 2000)
ISSN: 1524-4539 [Electronic] United States |
PMID | 10801755
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Vasodilator Agents
- Adenosine
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Topics |
- Adenosine
(administration & dosage, adverse effects)
- Aged
- Angioplasty, Balloon, Coronary
- Coronary Vessels
(drug effects, physiopathology)
- Electrocardiography
- Female
- Humans
- Male
- Middle Aged
- Myocardial Infarction
(physiopathology, therapy)
- Treatment Outcome
- Vasodilator Agents
(administration & dosage, adverse effects)
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