Analgesic principle from Abutilon indicum.

Abstract

Bioactivity guided isolation of Abutilon indicum yielded eugenol [4-allyl-2-methoxyphenol], which was found to possess significant analgesic activity. At doses of 10, 30, and 50 mg/kg body weight, eugenol exhibited 21.30 (p < 0.05), 42.25 (p < 0.01) and 92.96% (p < 0.001) inhibition of acetic acid induced writhing in mice. At a dose of 50 mg/kg body weight, eugenol showed 33.40% (p < 0.05) prolongation of tail flicking time determined by the radiant heat method.

• Authors: M Ahmed, S Amin, M Islam, M Takahashi, E Okuyama, C F Hossain
• Journal: Die Pharmazie (Pharmazie) Vol. 55 Issue 4 Pg. 314-6 (Apr 2000) ISSN: 0031-7144 [Print] Germany
• PMID: 10798248 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Acetates
• Analgesics
• Oils, Volatile
• eugenol-4-allyl-2-methoxyphenol
• Eugenol

Topics

• Acetates
• Analgesics (isolation & purification, pharmacology)
• Animals
• Chromatography, Thin Layer
• Eugenol (analogs & derivatives, isolation & purification, pharmacology)
• Hot Temperature
• Male
• Mice
• Oils, Volatile (chemistry)
• Pain Measurement (drug effects)
• Plants, Medicinal (chemistry)
• Rats