Abstract | BACKGROUND:
Neuroleptic medication is used extensively to treat people with chronic mental illnesses. However, it is associated with a wide range of adverse effects, including movement disorders. Because of this, many acutely psychotic patients being treated with neuroleptic medication also receive anticholinergic drugs in order to reduce some of the associated movement side-effects. OBJECTIVES: SEARCH STRATEGY: Electronic searches of Biological Abstracts (1982-1995), Cochrane Schizophrenia Group's Register of trials (1995), EMBASE (1980-1995), LILACS (1982-1996), MEDLINE (1966-1995), PsycLIT (1974-1995), and SCISEARCH (1995) were undertaken. References of all identified studies were searched for further trial citations. Principle authors of trials were contacted. SELECTION CRITERIA: DATA COLLECTION AND ANALYSIS: No data could be extracted from the seven randomised controlled trials identified. MAIN RESULTS: No data were synthesized. The authors have been contacted to provide the relevant information. Two studies were excluded because no data are available and six others are still awaiting further information from the authors. REVIEWER'S CONCLUSIONS: Based on currently available information, no confident statement can be made about the effectiveness of anticholinergics to treat people with neuroleptic-induced tardive dyskinesia. The same applies for the withdrawal of such medications. Whether the withdrawal of anticholinergics may benefit people with neuroleptic-induced TD, this should be evaluated in a parallel-group, placebo-controlled randomised trial, with adequate sample size and at least 6 weeks of follow up.
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Authors | K V Soares, J J McGrath |
Journal | The Cochrane database of systematic reviews
(Cochrane Database Syst Rev)
Issue 2
Pg. CD000204
( 2000)
ISSN: 1469-493X [Electronic] England |
PMID | 10796321
(Publication Type: Journal Article, Review, Systematic Review)
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Chemical References |
- Antipsychotic Agents
- Cholinergic Antagonists
|
Topics |
- Antipsychotic Agents
(adverse effects)
- Cholinergic Antagonists
(therapeutic use)
- Dyskinesia, Drug-Induced
(drug therapy, etiology)
- Humans
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