Abstract | BACKGROUND: METHODS:
Trabeculectomy with adjunctive mitomycin C was carried out unilaterally in 21 cases of normal-tension glaucoma. Intraocular pressure (IOP), visual prognosis, and complications were compared between the operated eyes and the non-operated fellow eyes. The follow-up period ranged from 2 to 7 years. RESULTS: The IOP dropped significantly from 14.8+/-1.8 mmHg (mean +/- SD) to 9.6+/-3.9 mmHg in the operated eyes (P=0.0002, Wilcoxon signed-rank test), but did not drop in the non-operated eyes. The mean deviation (MD) was -12.69+/-6.41 dB preoperatively and -14.70+/-5.49 dB at the last clinic visit in the operated eyes, whereas in non-operated eyes it was -7.85+/-5.65 dB and -11.15+/-5.62 dB, respectively. The MD deteriorated significantly in both operated and non-operated eyes (operated eyes P=0.0239, non-operated eyes: P=0.0002; Wilcoxon signed-rank test). The MD slope was -0.37+/-0.60 dB/year and -0.71+/-0.89 dB/year for the operated and non-operated eyes, respectively (P=0.5243, Mann-Whitney U-test). Visual field deterioration was more frequently observed in the non-operated eyes by a pointwise definition of the progression (P<0.05, McNemar test). Visual acuity deteriorated in 6 of the operated eyes and in 5 of the non-operated eyes. Cataract developed in 6 (29%) of the 21 operated eyes, while among the non-operated eyes 4 (19%) developed cataract. CONCLUSION:
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Authors | Y Hagiwara, T Yamamoto, Y Kitazawa |
Journal | Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
(Graefes Arch Clin Exp Ophthalmol)
Vol. 238
Issue 3
Pg. 232-6
(Mar 2000)
ISSN: 0721-832X [Print] Germany |
PMID | 10796038
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
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Topics |
- Adult
- Aged
- Chemotherapy, Adjuvant
- Disease Progression
- Female
- Glaucoma, Open-Angle
(drug therapy, physiopathology, surgery)
- Humans
- Intraocular Pressure
- Male
- Middle Aged
- Mitomycin
(therapeutic use)
- Postoperative Complications
- Prognosis
- Prospective Studies
- Trabeculectomy
- Vision Disorders
(physiopathology)
- Visual Acuity
- Visual Fields
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