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Opportunistic actinomycosis in osteoradionecrosis of the jaws in patients affected by head and neck cancer: incidence and clinical significance.

Abstract
Actinomycosis is occasionally an opportunistic infection occurrence in patients with osteoradionecrosis (ORN). A retrospective study (1992-97) of 50 patients with ORN of the jaws was done to evaluate the incidence and its clinical significance in the management of ORN. Actinomycosis was diagnosed in 12% of ORN cases. In 36 of the 50 patients including five cases of actinomycosis, the ORN was considered to be resolved after treatment. The median treatment duration of ORN was significantly longer (P<0.007) in patients with actinomycosis (29.7 months) than those without the disease (13.4 months). In conclusion, bone biopsy should be considered in cases of ORN with unsatisfactory response to its specific therapies, aiming to identify possible opportunistic actinomycosis infection.
AuthorsM M Curi, L L Dib, L P Kowalski, G Landman, C Mangini
JournalOral oncology (Oral Oncol) Vol. 36 Issue 3 Pg. 294-9 (May 2000) ISSN: 1368-8375 [Print] England
PMID10793333 (Publication Type: Journal Article)
Topics
  • Actinomycosis (diagnosis, epidemiology)
  • Adult
  • Aged
  • Female
  • Head and Neck Neoplasms (microbiology)
  • Humans
  • Incidence
  • Jaw Diseases (microbiology)
  • Male
  • Middle Aged
  • Opportunistic Infections (diagnosis, epidemiology)
  • Osteoradionecrosis (microbiology)
  • Retrospective Studies

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