Abstract | BACKGROUND: The effects of H. pylori eradication on atrophic body gastritis are controversial. AIM: To investigate the effect of triple therapy on atrophic body gastritis in H. pylori-positive patients and its effect on morpho-functional gastric parameters. METHODS: Thirty-five consecutive atrophic body gastritis patients with histological/serological evidence of H. pylori infection were treated. Before and 6 and 12 months after H. pylori eradication the patients were evaluated for fasting gastrinemia and pepsinogen I, basal and peak acid output, and detailed histological assessment including the ECL cell proliferative patterns. RESULTS: Six months after treatment, 25 out of 32 patients were cured (78%). Cure of infection was associated with improvement in both basal (basal acid output mean 0.23 +/- 0.14 mmol/h vs. 1.75 +/- 0.7 mmol/h, P < 0.005) and stimulated acid secretion (peak acid output mean 3.0 +/- 1.06 mmol/h vs. 16.6 +/- 4.1 mmol/h, P=0.0017) as well as with reduction in hypergastrinemia (mean gastrin levels 444.1 +/- 110.7 pg/mL vs. 85.3. +/- 28 pg/mL; P < 0.005). In contrast, the eradication had no effect on body corporal atrophy and intestinal metaplasia, or pepsinogen I levels (mean 16.6 +/- 2.9 ng/mL vs. 14.2 +/- 2.1 ng/mL, N.S.). These results were confirmed at 12 months after eradication. A statistical inverse correlation was obtained (r=-0.3635, P < 0.05) between the corporal chronic infiltrate score and peak acid output values. A total of 53% of atrophic body gastritis patients showed a regression in severity of body ECL cell hyperplastic change. CONCLUSION:
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Authors | B Annibale, M R Aprile, G D'ambra, P Caruana, C Bordi, G Delle Fave |
Journal | Alimentary pharmacology & therapeutics
(Aliment Pharmacol Ther)
Vol. 14
Issue 5
Pg. 625-34
(May 2000)
ISSN: 0269-2813 [Print] England |
PMID | 10792127
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adult
- Aged
- Enterochromaffin Cells
(pathology)
- Female
- Gastric Mucosa
(pathology)
- Gastrins
(blood)
- Gastritis, Atrophic
(drug therapy, pathology)
- Helicobacter Infections
(drug therapy)
- Helicobacter pylori
- Humans
- Hyperplasia
- Male
- Middle Aged
- Pepsinogen A
(blood, metabolism)
- Prospective Studies
- Treatment Outcome
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