Abstract |
C57BL/6J obese (ob/ob) and lean mice fed ad libitum on a normal mouse chow diet (Normal), were compared with lean mice of the same age and strain fed ad libitum on a high-fat diet, consisting of the Normal diet with the addition of beef lard ( Lard), from age 3 months for 34 days. The lard-fed mice were seen to have significantly higher (P<0.05) body weight in this 34-day period than that of the other two groups fed on the Normal diet. Epididymal fat depot and adipocyte cell size were significantly larger (P<0.05) in the Lard-fed lean mice and in the obese (ob/ob) mice than were those of the Normal-fed lean mice. Dietary Lard intake did not significantly affect concentrations of plasma triglyceride although those of plasma cholesterol were significantly increased (P<0.05). The development of obesity in these Lard-fed mice appeared to be accelerated and significant.
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Authors | R Libinaki, M Heffernan, W J Jiang, E Ogru, V Ignjatovic, R Gianello, L Trickey, M Taylor, F Ng |
Journal | IUBMB life
(IUBMB Life)
Vol. 48
Issue 1
Pg. 109-13
(Jul 1999)
ISSN: 1521-6543 [Print] England |
PMID | 10791924
(Publication Type: Journal Article)
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Chemical References |
- Dietary Fats
- Triglycerides
- Cholesterol
- lard
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Topics |
- Adipocytes
(cytology, pathology)
- Adipose Tissue
(anatomy & histology, metabolism)
- Animals
- Body Weight
- Cattle
- Cholesterol
(blood)
- Dietary Fats
- Lipolysis
- Mice
- Mice, Inbred C57BL
- Mice, Obese
- Obesity
(genetics, metabolism, physiopathology)
- Triglycerides
(blood)
- Weight Gain
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