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Effects of genetic and diet-induced obesity on lipid metabolism.

Abstract
C57BL/6J obese (ob/ob) and lean mice fed ad libitum on a normal mouse chow diet (Normal), were compared with lean mice of the same age and strain fed ad libitum on a high-fat diet, consisting of the Normal diet with the addition of beef lard (Lard), from age 3 months for 34 days. The lard-fed mice were seen to have significantly higher (P<0.05) body weight in this 34-day period than that of the other two groups fed on the Normal diet. Epididymal fat depot and adipocyte cell size were significantly larger (P<0.05) in the Lard-fed lean mice and in the obese (ob/ob) mice than were those of the Normal-fed lean mice. Dietary Lard intake did not significantly affect concentrations of plasma triglyceride although those of plasma cholesterol were significantly increased (P<0.05). The development of obesity in these Lard-fed mice appeared to be accelerated and significant.
AuthorsR Libinaki, M Heffernan, W J Jiang, E Ogru, V Ignjatovic, R Gianello, L Trickey, M Taylor, F Ng
JournalIUBMB life (IUBMB Life) Vol. 48 Issue 1 Pg. 109-13 (Jul 1999) ISSN: 1521-6543 [Print] England
PMID10791924 (Publication Type: Journal Article)
Chemical References
  • Dietary Fats
  • Triglycerides
  • Cholesterol
  • lard
Topics
  • Adipocytes (cytology, pathology)
  • Adipose Tissue (anatomy & histology, metabolism)
  • Animals
  • Body Weight
  • Cattle
  • Cholesterol (blood)
  • Dietary Fats
  • Lipolysis
  • Mice
  • Mice, Inbred C57BL
  • Mice, Obese
  • Obesity (genetics, metabolism, physiopathology)
  • Triglycerides (blood)
  • Weight Gain

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