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Superficial undifferentiated small cell carcinoma of the esophagus showing an interesting growing pattern in histology.

Abstract
We report a case of superficial undifferentiated small cell carcinoma of the esophagus. The histology of the tumor was interesting; there was squamous cell differentiation within the epithelial layer and undifferentiated small cells growing within the submucosal layer. The tumor had a negative Grimelius reaction, suggesting no differentiation into a hormone-producing carcinoma known as an apudoma (Amine Precursor Uptake and Decarboxylation (APUD)). The serum levels of ACTH and calcitonin were within normal limits. As the patient was elderly and had a history of pleural tuberculosis causing poor pulmonary function, and owing to the fulminant nature of this carcinoma, he underwent blunt dissection of the esophagus by posterior mediastinal gastric pull-up. The patient recovered quickly and was able to be discharged with a good quality of life until the tumor recurred as a liver metastasis 6 months later.
AuthorsY Fukunaga, S Hirata, S Tanimura, K Okawa, M Higashino, T Inoue, Y Kobayashi
JournalHepato-gastroenterology (Hepatogastroenterology) 2000 Mar-Apr Vol. 47 Issue 32 Pg. 429-32 ISSN: 0172-6390 [Print] Greece
PMID10791205 (Publication Type: Case Reports, Journal Article)
Topics
  • Aged
  • Carcinoma, Small Cell (diagnosis, pathology, surgery)
  • Cell Transformation, Neoplastic (pathology)
  • Epithelium (pathology)
  • Esophageal Neoplasms (diagnosis, pathology, surgery)
  • Esophagectomy
  • Esophagoscopy
  • Esophagus (pathology)
  • Humans
  • Male
  • Mucous Membrane (pathology)

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