Therapy of intention myoclonus with L-5-hydroxytryptophan and a peripheral decarboxylase inhibitor, MK 486.

Three patients with postanoxic intention myoclonus, two patients with intention tremor, and one patient with cerebral palsy were administered L-5-hydroxytryptophan (L-5HTP), the precursor of serotonin, in combination with MK 486, a peripheral amino acid decarboxylase inhibitor. L-5HTP combined with MK 486 were potent long-term therapeutic agents for postanoxic intention myoclonus, but had no effect on intention tremor or cerebral palsy. These drugs were well-tolerated by the patients, and more effective than any other known therapy for intention myoclonus. Cerebrospinal fluid concentration of 5-hydroxyindoleacetic acid, the main catabolite of serotonin, appeared low in two patients with intention myoclonus and increased markedly during drug therapy. Postanoxic intention myoclonus may be causally related to a deficiency of brain serotonin.
AuthorsM H Van Woert, V H Sethy
JournalNeurology (Neurology) Vol. 25 Issue 2 Pg. 135-40 (Feb 1975) ISSN: 0028-3878 [Print] UNITED STATES
PMID1078720 (Publication Type: Journal Article)
Chemical References
  • Aromatic Amino Acid Decarboxylase Inhibitors
  • Hydrazines
  • Serotonin
  • Hydroxyindoleacetic Acid
  • 5-Hydroxytryptophan
  • Carbidopa
  • Probenecid
  • Homovanillic Acid
  • Methysergide
  • 5-Hydroxytryptophan (administration & dosage, therapeutic use)
  • Adolescent
  • Adult
  • Anoxia (complications)
  • Aromatic Amino Acid Decarboxylase Inhibitors
  • Carbidopa (administration & dosage, therapeutic use)
  • Cerebral Palsy (drug therapy)
  • Drug Therapy, Combination
  • Female
  • Homovanillic Acid (cerebrospinal fluid)
  • Humans
  • Hydrazines (therapeutic use)
  • Hydroxyindoleacetic Acid (cerebrospinal fluid)
  • Male
  • Methysergide (therapeutic use)
  • Middle Aged
  • Myoclonus (cerebrospinal fluid, drug therapy, etiology)
  • Probenecid (cerebrospinal fluid, therapeutic use)
  • Serotonin (metabolism, physiology)

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