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Differences between cation-osmotic hemolysis and filterability in exaprolol- and glutaraldehyde-treated human red blood cells.

Abstract
The changes in human red blood cell microrheology in different glutaraldehyde (3.0 and 5.0 x 10(-6) mol x l(-1)) and exaprolol (2.5 and 5.0 x 10(-4) mol x l(-1)) concentrations were studied. The method of millipore filtration was compared with the method of cation-osmotic hemolysis. Both drugs prolonged the filtration time. Cation-osmotic hemolysis in glutaraldehyde-treated cells was significantly lower in comparison with the control group. On the other hand, there was a significant increase in cation-osmotic hemolysis in exaprolol-treated cells. Besides cation-osmotic hemolysis and filterability of erythrocytes, we evaluated the medium cell volume (MCV) and the medium cell hemoglobin concentration (MCHC). No changes in MCV and MCHC in glutaraldehyde-treated cells were observed. However, the MCV was significantly lower and the MCHC was significantly higher in exaprolol-treated cells. In conclusion, we suggest that the method of cation-osmotic hemolysis is more sensitive than the filtration method for determination of red blood cell microrheology.
AuthorsJ Mojzis, A Nicák, A Linková, M Jandoseková, L Mirossay
JournalPhysiological research (Physiol Res) Vol. 48 Issue 6 Pg. 411-6 ( 1999) ISSN: 0862-8408 [Print] Czech Republic
PMID10783905 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Adrenergic beta-Antagonists
  • Cations
  • Disinfectants
  • Propanolamines
  • exaprolol
  • Glutaral
Topics
  • Adrenergic beta-Antagonists (pharmacology)
  • Adult
  • Cations (pharmacology)
  • Disinfectants (pharmacology)
  • Erythrocyte Deformability (drug effects, physiology)
  • Glutaral (pharmacology)
  • Hemolysis (drug effects, physiology)
  • Humans
  • Middle Aged
  • Osmotic Pressure
  • Propanolamines (pharmacology)

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