Bactericidal/permeability-increasing protein prevents mucosal damage in an experimental rat model of chronic otitis media with effusion.

Abstract	In this study, the efficacy of bactericidal/permeability-increasing protein (BPI) was assessed in a rat model of chronic otitis media with effusion. BPI injection prevented disturbance of the mucociliary clearance system of the middle ear. Hence, it is postulated that BPI can be a new therapy for chronic otitis media with effusion.
Authors	M J Nell, H K Koerten, J J Grote
Journal	Infection and immunity (Infect Immun) Vol. 68 Issue 5 Pg. 2992-4 (May 2000) ISSN: 0019-9567 [Print] United States
PMID	10769000 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Anti-Infective Agents Antimicrobial Cationic Peptides Blood Proteins Lipopolysaccharides Membrane Proteins Recombinant Proteins bactericidal permeability increasing protein
Topics	Animals Anti-Infective Agents (therapeutic use) Antimicrobial Cationic Peptides Blood Proteins (therapeutic use) Chronic Disease Disease Models, Animal Ear, Middle (immunology, pathology) Lipopolysaccharides (administration & dosage, immunology) Membrane Proteins Mucous Membrane (injuries, pathology) Otitis Media with Effusion (drug therapy, immunology, pathology) Rats Recombinant Proteins (therapeutic use)

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