HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

[Local injection of depot corticosteroids in endoscopic therapy of benign bile duct strictures].

AbstractBACKGROUND:
Local injection of depot-corticosteroids into benign esophageal strictures has been proven to maintain the effects of bougienage or balloon dilation.
METHODS:
Eight consecutive patients with benign common bile duct (CBD)-strictures (postoperative, n = 6, primary-sclerosing cholangitis, n = 2) were enrolled in this pilot trial. All had undergone initial balloon dilation and insertion of a 10F-plastic prostheses without relevant effects on the stricture diameter four to six weeks before. Than all patients underwent another balloon dilation and insertion of a 10F-Tannenbaum-stent. In the same session injection of 2 x 10 mg of triamcinolone (Volon A, Bristol-Myers Squibb, München) into the CBD-wall at the stricture site by means of a sclerotherapy needle was performed. Four to six weeks later ERC was repeated and balloon dilation and/or stent exchange was performed whenever indicated.
RESULTS:
The initial mean diameter of the CBD-stenoses was 1.81 +/- 0.65 mm. The mean serum levels of the alkaline phosphatase (AP) and of bilirubin were 455 +/- 188 U/L and 4.9 +/- 2.2 mg/dl, respectively. After the initial balloon dilation and stent insertion no significant improvement had been registered (1.9 +/- 0.7 mm). However, after local triamcinolone injection and the second dilation/stent insertion the diameter of the CBD-stenosis increased significantly to 3.68 +/- 0.96 mm (p < 0.01). No adverse affects were recognized. Three patients had complete recovery of their CBD-stenosis after a third dilation, the remaining five patients were cured after two or three additional balloon dilations with intermittent stent exchange. Thereafter, no recurrence of a CBD-stenosis was observed during a median follow-up of twelve months. At completion of the study the mean serum AP- and bilirubin level were 195 +/- 87 U/L and 1.2 +/- 0.4 mg/dl, respectively.
CONCLUSION:
Local application of depot corticosteroids is a feasible and safe procedure for therapy of benign CBD-stenoses. The results of this pilot trial justify a randomized study.
AuthorsT Wehrmann, T Schmitt, W F Caspary, H Seifert
JournalZeitschrift fur Gastroenterologie (Z Gastroenterol) Vol. 38 Issue 3 Pg. 235-41 (Mar 2000) ISSN: 0044-2771 [Print] Germany
Vernacular TitleLokale Injektion von Depotkortikosteroiden bei der endoskopischen Therapie benigner Gallengangsstrikturen.
PMID10768246 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Glucocorticoids
  • Triamcinolone
Topics
  • Adult
  • Catheterization
  • Cholestasis, Extrahepatic (drug therapy, etiology)
  • Combined Modality Therapy
  • Common Bile Duct Diseases (drug therapy, etiology)
  • Female
  • Glucocorticoids (administration & dosage)
  • Humans
  • Injections, Intralesional
  • Liver Function Tests
  • Male
  • Middle Aged
  • Pilot Projects
  • Stents
  • Treatment Outcome
  • Triamcinolone (administration & dosage)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: