HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Progression of human breast cancers to the metastatic state is linked to genotypes of catechol-O-methyltransferase.

Abstract
There is increasing evidence that catecholestrogens may contribute to the development of breast cancer. Specifically, inactivation of catecholestrogens may prevent the genesis and arrest the progression of the disease. Catechol-O-methyltransferase (COMT), Glutathione S-transferase (GST) M1 and GSTP1 are responsible for the detoxification of catecholestrogens, and are polymorphic in the human population. In this study, a PCR-based restriction fragment length polymorphism analysis was performed to determine genotypes of the COMT, GSTM1 and GSTP1 genes. We investigated the relationship between the germline polymorphism of these genes and clinico-pathological characteristics in 140 patients with breast cancer. Among 73 patients with the low activity COMT allele, 49 (67%) had regional lymph node metastasis. On the other hand, only 27 (40%) of 67 patients without the low activity allele had lymph node metastasis. The COMT genotype was significantly associated with clinical stage and the extent of regional lymph node metastasis of breast cancer (P<0.05). However, polymorphisms of the GSTM1 and GSTP1 gene were not associated with clinico-pathological factors. Our findings suggest that the allele encoding for low activity COMT may contribute to the progression of breast cancer.
AuthorsA Matsui, T Ikeda, K Enomoto, H Nakashima, K Omae, M Watanabe, T Hibi, M Kitajima
JournalCancer letters (Cancer Lett) Vol. 150 Issue 1 Pg. 23-31 (Mar 13 2000) ISSN: 0304-3835 [Print] Ireland
PMID10755383 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Isoenzymes
  • Catechol O-Methyltransferase
  • GSTP1 protein, human
  • Glutathione S-Transferase pi
  • Glutathione Transferase
  • glutathione S-transferase M1
Topics
  • Adult
  • Breast Neoplasms (enzymology, pathology)
  • Catechol O-Methyltransferase (genetics)
  • Disease Progression
  • Female
  • Genotype
  • Glutathione S-Transferase pi
  • Glutathione Transferase (genetics)
  • Humans
  • Isoenzymes (genetics)
  • Middle Aged
  • Neoplasm Metastasis
  • Polymorphism, Genetic

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: