Abstract | OBJECTIVE: DESIGN: A prospective, clinical study. SETTING: General intensive care unit of a university hospital. PATIENTS: INTERVENTIONS: Patients received a meropenem dose of 1 g iv every 12 hrs as a 5-min bolus. MEASUREMENTS AND MAIN RESULTS:
Meropenem concentrations were measured by high-performance liquid chromatography in serum taken at timed intervals and in ultrafiltrate/ dialysate to determine serum concentration-time profiles, derive pharmacokinetic variable estimates, and determine sieving coefficients and filter clearances. The serum concentrations were examined to see whether they were above the minimum inhibitory concentrations (MICs) for pathogens that may be encountered in intensive care patients. Serum concentrations exceeded 4 mg/L (MIC90 for Pseudomonas aeruginosa) during 67% of the dosage period in all patients. Sub-MIC90 concentrations were obtained in three patients immediately before treatment and in one patient 12 hrs after treatment. Mean (SD) (n = 10) pharmacokinetic variable estimates were as follows: elimination half-life, 5.16 hrs (1.83 hrs); volume of distribution, 0.35 L/kg (0.10 L/kg); and total clearance, 4.30 L/hr (1.38 L/hr). A sieving coefficient of 0.93 (0.06) (n = 9) indicated free flow across the filter. The fraction cleared by the extracorporeal route was 48% (13%) (n = 9), which is clinically important. CONCLUSIONS:
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Authors | L J Giles, A C Jennings, A H Thomson, G Creed, R J Beale, A McLuckie |
Journal | Critical care medicine
(Crit Care Med)
Vol. 28
Issue 3
Pg. 632-7
(Mar 2000)
ISSN: 0090-3493 [Print] United States |
PMID | 10752806
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Acute Kidney Injury
(microbiology, therapy)
- Adult
- Aged
- Critical Care
- Female
- Half-Life
- Hemodiafiltration
- Hemofiltration
- Humans
- Injections, Intravenous
- Linear Models
- Male
- Meropenem
- Metabolic Clearance Rate
- Middle Aged
- Prospective Studies
- Sepsis
(complications, drug therapy)
- Thienamycins
(administration & dosage, pharmacokinetics)
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