Remission of relapsing childhood nephrotic syndrome with mycophenolate mofetil.

Abstract

We report a 21-year-old male with childhood-onset familial nephrotic syndrome and frequent relapses who manifested toxicity or treatment resistance to corticosteroids, cyclophosphamide, cyclosporin-A, and tacrolimus. Monotherapy with mycophenolate mofetil (MMF) resulted in maintenance of clinical remission for 14 months without noticeable toxicity, while allowing resolution of steroid-induced side effects. Our observation suggests that MMF may be useful in maintaining remission in nephrotic patients who manifest toxicity to standard immunosuppressive agents.

• Authors: M Chandra, M Susin, C Abitbol
• Journal: Pediatric nephrology (Berlin, Germany) (Pediatr Nephrol) Vol. 14 Issue 3 Pg. 224-6 (Mar 2000) ISSN: 0931-041X [Print] Germany
• PMID: 10752763 (Publication Type: Case Reports, Journal Article)

Chemical References

• Immunosuppressive Agents
• Mycophenolic Acid

Topics

• Child, Preschool
• Drug Resistance
• Humans
• Immunosuppressive Agents (adverse effects, therapeutic use)
• Male
• Mycophenolic Acid (analogs & derivatives, therapeutic use)
• Nephrotic Syndrome (drug therapy)
• Recurrence
• Remission Induction
• Retreatment