Ex juvantibus approach for chronic posterior laryngitis: results of short-term pantoprazole therapy.

Abstract

The aim of this study was to investigate whether patients with chronic posterior laryngitis and symptoms of gastro-pharyngeal reflux benefit from a six-week therapy with pantoprozole. Twenty-nine out-patients with voice disorders (case history of at least two months) and simultaneous symptoms of gastro-pharyngeal reflux were recruited for this study. At the entry to the study a symptom questionnaire and a video-laryngo/stroboscopy were completed. The symptom questionnaire and the video-laryngo/stroboscopy were repeated after the six weeks of therapy with pantoprazole 40 mg once a day and again six weeks and three months after this follow-up, during which time the patient was without therapy. Hoarseness, globus pharyngeus, sore throat, heartburn, and coughing were the symptoms which showed a significant (p < 0.05) recovery at the follow-ups (mean of hoarseness index: 7.28 to 0.92; mean of globus pharyngeus index: 3.14 to 0.58; mean of heartburn index: 2.86 to 0.5; mean of cough index: 1.72 to 0.25; mean of throat soreness index: 1.72 to 0.15). Laryngoscopy scores of the posterior laryngeal region, the glottic and the supraglottic region showed statistically significant improvement (p < 0.05) after the treatment with pantoprazole. The therapeutic effect exceeded the drug administration until the last follow-up (after three months). The medication was tolerated without side-effects in all patients. A primary (ex juvantibus) therapy with proton pump inhibitors seems to be a therapeutic option for patients with long-lasting chronic inflammation of the larynx not responding to common therapy. In this case a six-week course of treatment has been shown to be sufficient.

• Authors: W Habermann, A Eherer, F Lindbichler, J Raith, G Friedrich
• Journal: The Journal of laryngology and otology (J Laryngol Otol) Vol. 113 Issue 8 Pg. 734-9 (Aug 1999) ISSN: 0022-2151 [Print] England
• PMID: 10748849 (Publication Type: Journal Article)

Chemical References

• 2-Pyridinylmethylsulfinylbenzimidazoles
• Anti-Ulcer Agents
• Benzimidazoles
• Proton Pump Inhibitors
• Proton Pumps
• Sulfoxides
• Pantoprazole
• Omeprazole

Topics

• 2-Pyridinylmethylsulfinylbenzimidazoles
• Adult
• Anti-Ulcer Agents (therapeutic use)
• Benzimidazoles (therapeutic use)
• Chronic Disease
• Female
• Gastroesophageal Reflux (complications, drug therapy)
• Humans
• Laryngitis (drug therapy, etiology)
• Male
• Middle Aged
• Omeprazole (analogs & derivatives)
• Pantoprazole
• Proton Pump Inhibitors
• Proton Pumps (therapeutic use)
• Sulfoxides (therapeutic use)
• Surveys and Questionnaires
• Treatment Outcome
• Voice Disorders (drug therapy, etiology)