Comparative therapeutic efficacy of clinafloxacin in a pneumococcal meningitis mouse model.

Abstract

The therapeutic efficacy of clinafloxacin, a fluoroquinolone in clinical trials, was compared with that of ciprofloxacin and ceftriaxone in a novel pneumococcal meningitis mouse model. Mice were challenged by the intracerebral ventricular route with 50 IL of a lethal bacterial suspension and treated subcutaneously 2 h later. Both penicillin-susceptible and multidrug-resistant pneumococcal strains were used for evaluation. Survival percentages were calculated as the median curative dose (CD50) using log-probit statistical methods. Ceftriaxone was the most active agent against the penicillin-susceptible strain (CD50 = 2 mg/kg), but showed a 30-fold decrease in potency against the resistant strain. Clinafloxacin was equally effective against both strains, and proved to be the most active agent against the penicillin-resistant pneumococcus.

• Authors: M A Shapiro, K D Donovan, J W Gage
• Journal: The Journal of antimicrobial chemotherapy (J Antimicrob Chemother) Vol. 45 Issue 4 Pg. 489-92 (Apr 2000) ISSN: 0305-7453 [Print] England
• PMID: 10747826 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Anti-Infective Agents
• Cephalosporins
• Fluoroquinolones
• Ciprofloxacin
• Ceftriaxone
• clinafloxacin

Topics

• Animals
• Anti-Infective Agents (therapeutic use)
• Ceftriaxone (therapeutic use)
• Cephalosporins (therapeutic use)
• Ciprofloxacin (therapeutic use)
• Female
• Fluoroquinolones
• Meningitis, Pneumococcal (microbiology, prevention & control)
• Mice
• Microbial Sensitivity Tests
• Models, Biological
• Streptococcus pneumoniae (drug effects)