Abstract | BACKGROUND: METHODS: RESULTS: At baseline, the intensity of pruritus and the serum bile acid concentration were significantly related. Guar gum diminished or prevented worsening of pruritus, while in the placebo group pruritus was enhanced (p<0.05). In the placebo group serum bile acid concentration increased significantly, whereas in the guar gum group it remained unchanged (p<0.05 between the groups). Guar gum treatment-induced changes of the pruritus score and serum bile acid concentrations were significantly related (p<0.01). CONCLUSIONS:
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Authors | S Riikonen, H Savonius, H Gylling, K Nikkilä, A M Tuomi, T A Miettinen |
Journal | Acta obstetricia et gynecologica Scandinavica
(Acta Obstet Gynecol Scand)
Vol. 79
Issue 4
Pg. 260-4
(Apr 2000)
ISSN: 0001-6349 [Print] United States |
PMID | 10746839
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Bile Acids and Salts
- Dietary Fiber
- Galactans
- Mannans
- Plant Gums
- guar gum
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Topics |
- Administration, Oral
- Adult
- Bile Acids and Salts
(blood)
- Cholestasis, Intrahepatic
(complications, etiology)
- Dietary Fiber
(pharmacology, therapeutic use)
- Double-Blind Method
- Female
- Galactans
(pharmacology, therapeutic use)
- Humans
- Mannans
(pharmacology, therapeutic use)
- Plant Gums
- Pregnancy
- Pregnancy Complications
(drug therapy)
- Pruritus
(drug therapy, etiology)
- Treatment Outcome
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