Infantile tuberous sclerosis changes in the brain: proton MR spectroscopy findings.

Abstract

A parietal hamartoma of a three-month-old boy with tuberous sclerosis was studied with magnetic resonance (MR) imaging, and proton MR spectroscopy. MR spectra were obtained with the single-voxel PRESS (point resolved spectroscopy; TR = 1500 ms, TE = 135 ms) sequence, in a 8 cc region of interest. Apparently low NAA/Cho (0.28), and NAA/Cr (0.37) ratios were noted in the hamartoma, that could suggest a neoplasm. The lesion and the surrounding brain tissue were studied again after seven months with spectroscopic imaging using the chemical shift sequence (TR = 1500 ms. TE = 40 ms). This study revealed apparently improved NAA/Cho (2.63), NAA/Cr (2.13) ratios in the hamartoma compared to the initial examination at three months of age, excluding the possibility of a neoplasm.

• Authors: R N Sener
• Journal: Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society (Comput Med Imaging Graph) 2000 Jan-Feb Vol. 24 Issue 1 Pg. 19-24 ISSN: 0895-6111 [Print] United States
• PMID: 10739318 (Publication Type: Case Reports, Journal Article)

Chemical References

• Protons

Topics

• Brain Neoplasms (pathology)
• Humans
• Infant
• Magnetic Resonance Imaging (methods)
• Male
• Protons
• Tuberous Sclerosis (pathology)