MR-guided angioplasty of renal artery stenosis in a pig model: a feasibility study.

Abstract

PURPOSE:

To test the hypothesis that magnetic resonance (MR) imaging can guide the percutaneous treatment of renal artery stenosis in a pig model.

MATERIALS AND METHODS:

Ameroid constrictors were surgically placed around six renal arteries in four pigs. After 30-36 days, all stenoses were documented by conventional x-ray aortograms. MR-guided renal angioplasty was attempted for three stenoses. For these pigs, MR angiography was performed with use of contrast-enhanced three-dimensional (3D) techniques. The authors visualized catheters by filling them with dilute 4% gadolinium and imaging with two-dimensional (2D) and 3D MR fast spoiled gradient recalled echo techniques. Under MR guidance, the authors advanced a selective catheter into the affected renal artery and crossed the stenosis with a nitinol guide wire. Angioplasty was performed with a balloon catheter filled with dilute gadolinium. Stenosis and luminal diameter measurements were compared before and after angioplasty.

RESULTS:

After ameroid constrictor placement, four significant stenoses, one mild stenosis, and one occlusion developed. Under MR guidance, the authors achieved technical success in performing three of three (100%) attempted dilations. After MR-guided angioplasty, the mean reduction in stenosis was 35% and the mean increase in luminal diameter was 1.6 mm.

CONCLUSION:

Use of MR guidance for the angioplasty of renal artery stenosis in pigs is feasible.

• Authors: R A Omary, R Frayne, O Unal, T Warner, F R Korosec, C A Mistretta, C M Strother, T M Grist
• Journal: Journal of vascular and interventional radiology : JVIR (J Vasc Interv Radiol) Vol. 11 Issue 3 Pg. 373-81 (Mar 2000) ISSN: 1051-0443 [Print] United States
• PMID: 10735435 (Publication Type: Comparative Study, Journal Article)

Topics

• Angioplasty, Balloon (methods)
• Animals
• Disease Models, Animal
• Feasibility Studies
• Magnetic Resonance Angiography
• Renal Artery (pathology)
• Renal Artery Obstruction (diagnosis, therapy)
• Swine