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Carbamazepine-induced Stevens-Johnson syndrome treated with IV steroids and IVIG.

Abstract
A 17-year-old female is presented who developed antiepileptic drug hypersensitivity syndrome after treatment with carbamazepine. The initial diagnoses were idiopathic thrombocytopenic purpura and toxic shock syndrome. The patient was treated with intravenous immunoglobulin and intravenous steroids. After a severe climax on days 2-4 she recovered completely and was discharged on the eighth day of hospitalization. Although we do not have direct proof, we believe that these treatment modalities, especially the IVIG, shortened and ameliorated the clinical course of the disease.
AuthorsR Straussberg, L Harel, D Ben-Amitai, D Cohen, J Amir
JournalPediatric neurology (Pediatr Neurol) Vol. 22 Issue 3 Pg. 231-3 (Mar 2000) ISSN: 0887-8994 [Print] United States
PMID10734256 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Anti-Inflammatory Agents
  • Anticonvulsants
  • Immunoglobulins, Intravenous
  • Carbamazepine
  • Methylprednisolone
Topics
  • Adolescent
  • Anti-Inflammatory Agents (administration & dosage, therapeutic use)
  • Anticonvulsants (adverse effects)
  • Carbamazepine (adverse effects)
  • Female
  • Humans
  • Immunoglobulins, Intravenous (administration & dosage, therapeutic use)
  • Infusions, Intravenous
  • Methylprednisolone (administration & dosage, therapeutic use)
  • Stevens-Johnson Syndrome (chemically induced, drug therapy)
  • Treatment Outcome

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