Successful treatment of disseminated nasal NK/T-cell lymphoma using double autologous peripheral blood stem cell transplantation.

Abstract

Nasal natural killer (NK)/T-cell lymphoma is a rare disease with an aggressive clinical course. Prognosis is generally poor and the disease is invariably fatal after systemic dissemination. We report a patient with aggressive nasal NK/T-cell lymphoma who was resistant to therapy and developed systemic dissemination involving the intestine, skin, and stomach. Epstein-Barr virus (EBV) was detected by Southern blotting with EBV-terminal repeat probe and by in situ EBV-encoded small nuclear early region-1 hybridization. The patient was treated using double high-dose chemotherapy and autologous peripheral blood stem cell transplantation (auto-PBSCT). Pretransplant conditioning for the first auto-PBSCT was MCVC (high-dose ranimustine, carboplatin, etoposide [VP16], and cyclophosphamide), and for the second auto-PBSCT, modified ICE (high-dose ifosfamide, VP16, and carboplatin). The patient obtained a complete remission and has been free of disease for 3.0 years since the second PBSCT. These observations suggest that double high-dose chemotherapy with PBSCT support may be effective in resistant nasal NK/T-cell lymphoma.

• Authors: M Sasaki, K Matsue, M Takeuchi, M Mitome, Y Hirose
• Journal: International journal of hematology (Int J Hematol) Vol. 71 Issue 1 Pg. 75-8 (Jan 2000) ISSN: 0925-5710 [Print] Japan
• PMID: 10729998 (Publication Type: Case Reports, Journal Article)

Chemical References

• RNA, Viral

Topics

• Adult
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Disease-Free Survival
• Female
• Hematopoietic Stem Cell Transplantation
• Herpesvirus 4, Human (genetics)
• Humans
• Japan (ethnology)
• Killer Cells, Natural (pathology)
• Lymphoma, Non-Hodgkin (therapy)
• Lymphoma, T-Cell (therapy)
• Nasopharyngeal Neoplasms (therapy)
• RNA, Viral (blood)
• Transplantation, Autologous