[A comparative efficacy study of the preoperative use of GnRH agonists in women with uterine fibromyomas].

Abstract

The aim of the study is to establish the efficacy of preoperative use of GnRH agonists in women with uterine fibromyomas. The study is a randomized prospective one and includes 34 patients, divided in two groups: group I--with preoperative application of GnRH agonists--Zoladex and group II--without medication. In Zoladex group amenorrhea was achieved in 76% of patients after 7-8 weeks of treatment. After a 3-months treatment with Zoladex Hb levels increased from 8.9 +/- 0.9 gl/l to 11.7 +/- 1.2 g/l; levels of serum Fe--from 7.3 +/- 4 mumol/l to 18.5 +/- 5 mumol/l. Total uterine volume decreased by 30% before surgery (from 328 +/- 85 ml to 233 +/- 61 ml), while myoma volume decreased by 39% (from 178 +/- 62 ml to 109 +/- 44 ml). Mean blood loss during surgery (hysterectomy) is definitely less in patients, treated with Zoladex--194 +/- 75 ml., compared to 287 +/- 102 ml in control group. The significant reduction in myoma volume in 6 patients due to presurgical treatment with Zoladex made smaller operation--myomectomy, possible. Side effects, related to GnRH agonist Zoladex, are well tolerated and transitory and did not lead to retreatment from the trial.

• Authors: A Nikolov, I Karag'ozov
• Journal: Akusherstvo i ginekologiia (Akush Ginekol (Sofiia)) Vol. 38 Issue 4 Pg. 38-42 ( 1999) ISSN: 0324-0959 [Print] Bulgaria
• Vernacular Title: Sravnitelno prouchvane efektivnostta ot preoperativno prilozhenie na GnRH agonisti pri zheni s fibromioma na matkata.
• PMID: 10726353 (Publication Type: Clinical Trial, Comparative Study, English Abstract, Journal Article, Randomized Controlled Trial)

Chemical References

• Antineoplastic Agents, Hormonal
• Goserelin
• Gonadotropin-Releasing Hormone

Topics

• Adult
• Analysis of Variance
• Antineoplastic Agents, Hormonal (therapeutic use)
• Chemotherapy, Adjuvant (statistics & numerical data)
• Female
• Gonadotropin-Releasing Hormone (agonists)
• Goserelin (therapeutic use)
• Humans
• Leiomyoma (drug therapy, surgery)
• Middle Aged
• Preoperative Care (statistics & numerical data)
• Prospective Studies
• Time Factors
• Uterine Neoplasms (drug therapy, surgery)