Abstract | OBJECTIVE: METHODS: We conducted an open randomized multicenter study of neonatal outcome in 185 women who received either oral nifedipine (n = 95) or intravenous (IV) ritodrine (n = 90) for treatment of preterm labor. Secondary outcome measures included neonatal mortality and morbidity, especially neonatal intensive care unit (NICU) admission, respiratory distress syndrome (RDS), and intracranial bleeding. RESULTS: There were no significant differences in umbilical artery pH values and Apgar scores between groups. Nifedipine was associated with lower admission rates to the NICU (49% versus 66%; odds ratio 0. 51, confidence interval 0.28, 0.93) compared with ritodrine, and lower incidences of RDS (21% versus 37%; 0.46, 0.24, 0.89), intracranial bleeding (18% versus 31%; 0.48, 0.24, 0.96), and neonatal jaundice (52% versus 67%; 0.53, 0.29, 0.97). Logistic regression analysis showed that even after correction for gestational age at birth, newborn risk of RDS, intracranial bleeding, or neonatal jaundice was significantly lower in the nifedipine group than the ritodrine group. CONCLUSION:
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Authors | D N Papatsonis, J H Kok, H P van Geijn, O P Bleker, H J Adèr, G A Dekker |
Journal | Obstetrics and gynecology
(Obstet Gynecol)
Vol. 95
Issue 4
Pg. 477-81
(Apr 2000)
ISSN: 0029-7844 [Print] United States |
PMID | 10725475
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial)
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Chemical References |
- Tocolytic Agents
- Ritodrine
- Nifedipine
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Topics |
- Adult
- Female
- Humans
- Infant, Newborn
- Infant, Newborn, Diseases
(epidemiology, etiology)
- Male
- Nifedipine
(therapeutic use)
- Obstetric Labor, Premature
(prevention & control)
- Pregnancy
- Ritodrine
(therapeutic use)
- Tocolytic Agents
(therapeutic use)
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