Abstract |
The clinical and bacteriological efficacy of a 3-day course of pivmecillinam, 200 mg three times daily, was compared with that of a 7-day course of cephalexin, 250 mg four times daily, in 216 patients with a bacteriologically confirmed, acute, uncomplicated, urinary tract infection. Both treatments were similarly effective. Clinical cure or improvement was obtained in 95.3% of patients given pivmecillinam and in 93.6% of patients given cephalexin. Bacteriological success was achieved in 89.7 and 81.7% patients taking pivmecillinam or cephalexin, respectively. Eradication rates for Escherichia coli were 90.1% for pivmecillinam and 80.6% for cephalexin. Both treatments were well tolerated. This study has confirmed that a 3-day course of pivmecillinam is effective and well tolerated in uncomplicated cystitis.
|
Authors | A P Menday |
Journal | International journal of antimicrobial agents
(Int J Antimicrob Agents)
Vol. 13
Issue 3
Pg. 183-7
(Jan 2000)
ISSN: 0924-8579 [Print] Netherlands |
PMID | 10724022
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
|
Chemical References |
- Amdinocillin Pivoxil
- Cephalexin
|
Topics |
- Acute Disease
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Amdinocillin Pivoxil
(administration & dosage, adverse effects, therapeutic use)
- Bacterial Infections
(drug therapy, microbiology)
- Cephalexin
(administration & dosage, adverse effects, therapeutic use)
- Cystitis
(drug therapy, microbiology)
- Double-Blind Method
- Escherichia coli Infections
(drug therapy)
- Female
- Flushing
(chemically induced)
- Hot Flashes
(chemically induced)
- Humans
- Male
- Middle Aged
- Nausea
(chemically induced)
- Urinary Tract Infections
(drug therapy, microbiology)
|