Applications of (7)Li NMR in biomedicine.

Abstract

The applications of (7)Li NMR spectroscopy and imaging in biology and experimental medicine have been progressing steadily. The interest derives primarily from the clinical use of Li salts to treat mania and manic-depressive illness. One area of investigation is ionic transport across the cellular membrane and compartmentation, so as to elucidate the mechanism(s) of therapeutic action and toxicity in clinical practice. The second is the development of a noninvasive, in vivo analytical tool to measure brain Li concentrations in humans, both as an adjunct to treatment and as a mechanistic probe. Here we review progress to date in this area.

• Authors: R A Komoroski
• Journal: Magnetic resonance imaging (Magn Reson Imaging) Vol. 18 Issue 2 Pg. 103-16 (Feb 2000) ISSN: 0730-725X [Print] Netherlands
• PMID: 10722969 (Publication Type: Journal Article, Review)

Chemical References

• Lithium Carbonate
• Lithium

Topics

• Animals
• Biological Availability
• Bipolar Disorder (drug therapy, metabolism)
• Brain (metabolism)
• Cells, Cultured
• Humans
• Lithium (pharmacokinetics)
• Lithium Carbonate (pharmacokinetics, therapeutic use)
• Magnetic Resonance Imaging
• Metabolic Clearance Rate (physiology)