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Adenosine receptors are involved in the control of acute naloxone-precipitated withdrawal: in vitro evidence.

Abstract
The effects exerted by adenosine A1 and A2 receptor agonists and antagonists on the acute opiate withdrawal induced by morphine were investigated in vitro. Following a 4 min in vitro exposure to morphine, the guinea-pig isolated ileum exhibited a strong contracture after the addition of naloxone. The P1 adenosine receptor agonist, adenosine, was able to reduce dose-dependently naloxone-precipitaded withdrawal. The same effect was induced by the adenosine A1 receptor agonist, N6-Cyclopentyladenosine (CPA) whereas the selective adenosine A2A receptor agonist CGS 21680 increased the naloxone-precipitated withdrawal phenomenon. Dipyridamole, a blocker of adenosine reuptake, induced a significant reduction of morphine dependence. Caffeine, an adenosine receptor antagonist, significantly increased the naloxone-precipitated withdrawal effect in a concentration dependent manner. The same effect was observed with 8-phenyltheophylline (8PT), an A1 adenosine receptor antagonist, whereas 3,7-dimethyl-1-propargylxanthine (DMPX), an A2 adenosine receptor antagonist, reduced the naloxone-precipitated withdrawal phenomenon. The results of our experiments indicate that both A1 and A2 adenosine receptor agonists and antagonists are able to influence opiate withdrawal in vitro, suggesting an important functional interaction between the adenosine receptors and opioid withdrawal.
AuthorsA Capasso
JournalLife sciences (Life Sci) Vol. 66 Issue 10 Pg. 873-83 ( 2000) ISSN: 0024-3205 [Print] Netherlands
PMID10714888 (Publication Type: Journal Article)
Chemical References
  • Narcotic Antagonists
  • Phenethylamines
  • Purinergic P1 Receptor Agonists
  • Purinergic P1 Receptor Antagonists
  • Receptors, Purinergic P1
  • 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine
  • Naloxone
  • Caffeine
  • N(6)-cyclopentyladenosine
  • 3,7-dimethyl-1-propargylxanthine
  • Dipyridamole
  • Theophylline
  • 8-phenyltheophylline
  • Adenosine
  • Theobromine
Topics
  • Adenosine (analogs & derivatives, pharmacology)
  • Animals
  • Caffeine (pharmacology)
  • Dipyridamole (pharmacology)
  • Guinea Pigs
  • Ileum (drug effects, physiology)
  • In Vitro Techniques
  • Male
  • Naloxone (pharmacology)
  • Narcotic Antagonists (pharmacology)
  • Phenethylamines (pharmacology)
  • Purinergic P1 Receptor Agonists
  • Purinergic P1 Receptor Antagonists
  • Receptors, Purinergic P1 (physiology)
  • Substance Withdrawal Syndrome
  • Theobromine (analogs & derivatives, pharmacology)
  • Theophylline (analogs & derivatives, pharmacology)

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