Abstract |
In patients with chronic pancreatitis (CP) the relation among exocrine pancreatic secretion, gastrointestinal hormone release, and motility is disturbed. We studied digestive and interdigestive antroduodenal motility and postprandial gut hormone release in 26 patients with CP. Fifteen of these patients had pancreatic insufficiency (PI) established by urinary para-aminobenzoic acid test and fecal fat excretion. Antroduodenal motility was recorded after ingestion of a mixed liquid meal. The effect of pancreatic enzyme supplementation was studied in 8 of the 15 CP patients with PI. The duration of the postprandial antroduodenal motor pattern was significantly (P < 0.01) prolonged in CP patients (324 +/- 20 min) compared with controls (215 +/- 19 min). Antral motility indexes in the first hour after meal ingestion were significantly reduced in CP patients. The interdigestive migrating motor complex cycle length was significantly (P < 0.01) shorter in CP patients (90 +/- 8 min) compared with controls (129 +/- 8 min). These abnormalities were more pronounced in CP patients with exocrine PI. After supplementation of pancreatic enzymes, these alterations in motility reverted toward normal. Digestive and interdigestive antroduodenal motility are abnormal in patients with CP but significantly different from controls only in those with exocrine PI. These abnormalities in antroduodenal motility in CP are related to maldigestion.
|
Authors | M K Vu, J Vecht, E H Eddes, I Biemond, C B Lamers, A A Masclee |
Journal | American journal of physiology. Gastrointestinal and liver physiology
(Am J Physiol Gastrointest Liver Physiol)
Vol. 278
Issue 3
Pg. G458-66
(Mar 2000)
ISSN: 0193-1857 [Print] United States |
PMID | 10712266
(Publication Type: Journal Article)
|
Chemical References |
- Enzymes
- Peptide YY
- Pancreatic Polypeptide
- Cholecystokinin
|
Topics |
- Adult
- Aged
- Cholecystokinin
(blood)
- Chronic Disease
- Diabetes Mellitus, Type 1
(complications, physiopathology)
- Digestion
- Duodenum
(physiopathology)
- Eating
- Enzymes
(pharmacology)
- Female
- Gastrointestinal Motility
- Humans
- Islets of Langerhans
(physiopathology)
- Male
- Middle Aged
- Pancreas
(enzymology, physiopathology)
- Pancreatic Polypeptide
(blood)
- Pancreatitis
(complications, physiopathology)
- Peptide YY
(blood)
|