In vitro activity of gemifloxacin (SB 265805; LB20304a) against human mycoplasmas.

The in vitro activity of gemifloxacin, a new broad-spectrum fluoroquinolone, was compared with those of ciprofloxacin, erythromycin, azithromycin and doxycycline against 29 human respiratory or urogenital tract mycoplasmas. Gemifloxacin was highly active against all of the mycoplasma and ureaplasma species tested (MIC range 0.001-0.25 mg/L) and was 5- to 100-fold more active than ciprofloxacin. Doxycycline was less active than gemifloxacin against the mycoplasmas (MIC range 0.01-1 mg/L) but had similar activity against Ureaplasma urealyticum (MIC ranges 0.025-0.25 mg/L and 0.1-0. 25 mg/L, respectively). The macrolides, particularly azithromycin, were more active than gemifloxacin against Mycoplasma pneumoniae (MIC range 0.001-0.0025 mg/L) and Mycoplasma genitalium (0.0005-0. 001 mg/L) isolates but were less active against Mycoplasma fermentans and U. urealyticum and inactive against Mycoplasma hominis. Gemifloxacin may therefore be useful in the treatment of respiratory, urogenital or systemic mycoplasma infections in humans.
AuthorsP C Hannan, G Woodnutt
JournalThe Journal of antimicrobial chemotherapy (J Antimicrob Chemother) Vol. 45 Issue 3 Pg. 367-9 (Mar 2000) ISSN: 0305-7453 [Print] ENGLAND
PMID10702559 (Publication Type: Journal Article)
Chemical References
  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Fluoroquinolones
  • Naphthyridines
  • gemifloxacin
  • Anti-Bacterial Agents (pharmacology)
  • Anti-Infective Agents (pharmacology)
  • Fluoroquinolones
  • Humans
  • Microbial Sensitivity Tests
  • Mycoplasma (drug effects)
  • Mycoplasma Infections (microbiology)
  • Naphthyridines (pharmacology)
  • Ureaplasma urealyticum (drug effects)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: