Abstract |
The possibility of safe implementation of neoadjuvant chemotherapy using nedaplatin (254-S) was investigated with the aim of improving the therapeutic results in advanced esophageal cancer patients. The subjects had usually undergone two courses of 254-S, 80 or 100 mg/m2, preoperatively, at intervals of 4 weeks. After chemotherapy, responses were evaluated, and resection was undertaken 4 weeks after the final administration. The subjects were 10 patients with untreated esophageal cancer. As a result of evaluation of responses of main lesions to chemotherapy, a partial response (PR) was observed in 3 patients, and a minor response 3, showing an efficacy rate of 30%. Pathological findings before treatment were determined by staining of a cell cycle marker (Ki-67). The 3 patients who were evaluated as PR (clinical efficacy) showed high rates of positivity for Ki-67 of 47.4%, 52.7%, and 86%, respectively. There were no serious complications and no death related to operation. The observations suggested that 254-S, which has little or no side effects including nephrotoxicity, can become the standard remedy for esophageal cancer instead of CDDP in future.
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Authors | S Hirata, E Yatsuyanagi, H Yamazaki, Y Sugimoto, S Kosiko, T Kokubo, Y Atsuta, T Sasajima, N Miyokawa |
Journal | Gan to kagaku ryoho. Cancer & chemotherapy
(Gan To Kagaku Ryoho)
Vol. 27
Issue 2
Pg. 221-6
(Feb 2000)
ISSN: 0385-0684 [Print] Japan |
PMID | 10700891
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Antineoplastic Agents
- Ki-67 Antigen
- Organoplatinum Compounds
- Tumor Suppressor Protein p53
- nedaplatin
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Topics |
- Aged
- Antineoplastic Agents
(administration & dosage)
- Cell Cycle
- Drug Administration Schedule
- Esophageal Neoplasms
(blood, drug therapy, pathology)
- Female
- Humans
- Ki-67 Antigen
(blood)
- Male
- Middle Aged
- Neoadjuvant Therapy
- Organoplatinum Compounds
(administration & dosage)
- Preoperative Care
- Tumor Suppressor Protein p53
(blood)
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