Intraperitoneal and intraamygdala N(6)-cyclohexyladenosine suppress hippocampal kindled seizures in rats.

Abstract

Effects of intraperitoneal and intraamygdala N(6)-cyclohexyladenosine (CHA), a selective adenosine A(1) receptor agonist, and 1,3-dimethyl-8-cyclopentylxanthine (CPT), a selective adenosine A(1) receptor antagonist, were examined in fully hippocampal kindled rats. Intraperitoneal administration of CHA (0. 25, 0.5 and 1 mg/kg) decreased hippocampal secondary afterdischarge duration (SAD) and amygdala afterdischarge duration (ADD). Only the 1 mg/kg dose induced a significant increase in latency to stage 4. Intraperitoneal administration of CPT (0.25, 0.5 and 1 mg/kg) induced a significant increase in stage 5 duration, hippocampal SAD and ADD. Pretreatment of animals with CPT (1 mg/kg), antagonized effects of CHA on seizure parameters. Intraamygdala microinfusion (1 microl over 2 min) of CHA (5 nM-1 mM) significantly reduced hippocampal SAD and amygdala ADD. These effects were antagonized by intraamygdala CPT (1 microM). Results obtained suggest that in hippocampal kindled rats, amygdala may be regarded as a relay point for AD propagation specially in recruit activity of the hippocampus.

• Authors: J Mirnajafi-Zadeh, Y Fathollahi, M H Pourgholami
• Journal: Brain research (Brain Res) Vol. 858 Issue 1 Pg. 48-54 (Mar 06 2000) ISSN: 0006-8993 [Print] Netherlands
• PMID: 10700595 (Publication Type: Journal Article)

Chemical References

• 1,3-dimethyl-8-cyclopentylxanthine
• Anticonvulsants
• Purinergic P1 Receptor Agonists
• Purinergic P1 Receptor Antagonists
• Xanthines
• N(6)-cyclohexyladenosine
• Adenosine

Topics

• Adenosine (administration & dosage, analogs & derivatives, antagonists & inhibitors)
• Amygdala (drug effects, physiopathology)
• Animals
• Anticonvulsants (administration & dosage)
• Behavior, Animal (drug effects)
• Dose-Response Relationship, Drug
• Drug Antagonism
• Electric Stimulation
• Hippocampus (drug effects, physiopathology)
• Injections, Intraperitoneal
• Kindling, Neurologic (drug effects)
• Male
• Microinjections
• Purinergic P1 Receptor Agonists
• Purinergic P1 Receptor Antagonists
• Rats
• Rats, Sprague-Dawley
• Reaction Time (drug effects)
• Seizures (prevention & control)
• Xanthines (administration & dosage)