Importance of synovial fluid aspiration when injecting intra-articular corticosteroids.

The aim of this prospective study was to find if a complete synovial fluid aspiration before injecting intra-articular corticosteroids influences the treatment result.
The study was performed in 147 patients with rheumatoid arthritis (RA). One hundred and ninety one knees with synovitis were randomised to arthrocentesis (n=95) or no arthrocentesis (n = 96) before 20 mg triamcinolone hexacetonide was injected. The duration of effect was followed up for a period of six months. All patients were instructed to contact the rheumatology department if signs and symptoms from the treated knee recurred. If arthritis could be confirmed by a clinical examination a relapse was noted.
There was a significant reduction of relapse in the arthrocentesis group (p = 0.001).
The study shows that aspiration of synovial fluid can reduce the risk for arthritis relapse when treating RA patients with intra-articular corticosteroids. It is concluded that arthrocentesis shall be included in the intra-articular corticosteroid injection procedure.
AuthorsT Weitoft, P Uddenfeldt
JournalAnnals of the rheumatic diseases (Ann Rheum Dis) Vol. 59 Issue 3 Pg. 233-5 (Mar 2000) ISSN: 0003-4967 [Print] ENGLAND
PMID10700435 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Anti-Inflammatory Agents
  • Triamcinolone Acetonide
  • triamcinolone hexacetonide
  • Administration, Topical
  • Adult
  • Aged
  • Aged, 80 and over
  • Anti-Inflammatory Agents (administration & dosage, therapeutic use)
  • Arthritis, Rheumatoid (drug therapy)
  • Female
  • Follow-Up Studies
  • Humans
  • Injections, Intra-Articular
  • Knee Joint
  • Male
  • Middle Aged
  • Prospective Studies
  • Suction
  • Synovial Fluid
  • Synovitis (drug therapy)
  • Triamcinolone Acetonide (administration & dosage, analogs & derivatives, therapeutic use)

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