Gonadotropin treatment of hypogonadotropic hypogonadal adolescents.

Abstract

Testosterone substitution, needed for normal physical development in male hypogonadal adolescents, does not induce testicular growth. We treated 37 hypogonadal adolescents with gonadotropins (hCG/hMG), to obtain complete virilization during the first two years of treatment, to avoid psychological sequellae and to allow normal sexual development. Testicular volume increased significantly during therapy (from 1.98 +/- 1.2 to 9 +/- 3.3 ml), while testosterone rose from 0.26 +/- 0.04 to 5.3 +/- 0.8 ng/ml, with worse results in adolescents with cryptorchidism. hCG/hMG treatment had a better outcome than testosterone during the induction of puberty, avoiding psychological problems induced by atrophic testes. Further long term studies are necessary to evaluate whether early hCG/hMG treatment facilitates later spermatogenesis even in patients with cryptorchidism.

• Authors: C Bouvattier, M Tauber, B Jouret, J L Chaussain, P Rochiccioli
• Journal: Journal of pediatric endocrinology & metabolism : JPEM (J Pediatr Endocrinol Metab) Vol. 12 Suppl 1 Pg. 339-44 (Apr 1999) ISSN: 0334-018X [Print] Germany
• PMID: 10698599 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Chorionic Gonadotropin
• Testosterone
• Menotropins

Topics

• Adolescent
• Adult
• Body Height (drug effects)
• Chorionic Gonadotropin (administration & dosage, adverse effects, pharmacology, therapeutic use)
• Cryptorchidism (complications, drug therapy, pathology, psychology)
• Drug Therapy, Combination
• Hormone Replacement Therapy
• Humans
• Hypogonadism (complications, drug therapy, physiopathology, psychology)
• Libido (drug effects)
• Male
• Menotropins (administration & dosage, adverse effects, pharmacology, therapeutic use)
• Puberty (drug effects, metabolism, physiology, psychology)
• Sexual Maturation (drug effects, physiology)
• Sperm Count (drug effects)
• Testis (drug effects, growth & development, pathology, physiopathology)
• Testosterone (administration & dosage, blood, pharmacology, therapeutic use)