[Essential thrombocythemia in transformation from myelodysplastic syndrome to acute myeloid leukemia with inv(3) after treatment for gastric cancer].

Abstract

In March 1990, a 61-year-old man was given a diagnosis of essential thrombocythemia with a normal karyotype and subsequently treated with hydroxyurea. In November 1995, he underwent surgery for gastric cancer with thereafter received tegafur/uracil for 2 years. Refractory anemia with excess of blasts in transformation and chromosomal abnormalities including -5, -7, 20q-developed in August 1998. Combined chemotherapy with daunorubicin, cytarabine, mercaptopurine, and prednisolone, had only limited effectiveness. Acute myeloid leukemia was finally diagnosed in October 1998, and chromosomal analysis disclosed inv(3) in addition to -5 and -7. The appearance of inv(3) might be related to leukemic transformation of hematopoietic stem cell disease with an increase in the number of megakaryocytes and platelets.

• Authors: M Horikoshi, U Machida, M Itikawa, S Seo, S Masuda, M Kurokawa, S Ogawa, S Sunaga, H Honda, K Aoki, S Chiba, K Mitani, H Hirai, Y Yazaki
• Journal: [Rinsho ketsueki] The Japanese journal of clinical hematology (Rinsho Ketsueki) Vol. 41 Issue 1 Pg. 68-71 (Jan 2000) ISSN: 0485-1439 [Print] Japan
• PMID: 10695403 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Tegafur
• Uracil
• Hydroxyurea

Topics

• Aged
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Chromosome Inversion
• Chromosomes, Human, Pair 3 (genetics)
• Fatal Outcome
• Gastrectomy
• Humans
• Hydroxyurea (therapeutic use)
• Karyotyping
• Leukemia, Myeloid, Acute (genetics, pathology)
• Male
• Myelodysplastic Syndromes (pathology)
• Neoplasms, Second Primary
• Stomach Neoplasms (therapy)
• Tegafur (administration & dosage)
• Thrombocythemia, Essential (complications, drug therapy)
• Uracil (administration & dosage)