Novel polymorphism in the coding region of the IL-13 receptor alpha' gene: association study with atopic asthma in the Japanese population.

Abstract

Interleukin (IL)-4 and IL-13 play key roles in the development of atopic asthma. The IL-13 receptor (R) alpha' chain is a component of both IL-4R and IL-13R complexes. By screening the whole coding region of the IL-13Ralpha' gene for polymorphisms, we identified a new polymorphism at nucleotide position 1050 from the ATG start codon. The allelic frequency of the C/T polymorphism in the Japanese population was found to be 0.97:0.03. Because of the low frequency of the T allele, the association study failed to indicate any significant association between this polymorphism and atopic asthma in the Japanese population. Further studies are required in other racial groups with higher frequencies of this polymorphism to elucidate the association.

• Authors: S Ahmed, K Ihara, Y Sasaki, F Nakao, S Nishima, T Fujino, T Hara
• Journal: Experimental and clinical immunogenetics (Exp Clin Immunogenet) Vol. 17 Issue 1 Pg. 18-22 ( 2000) ISSN: 0254-9670 [Print] Switzerland
• PMID: 10686479 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright 2000 S. Karger AG, Basel

Chemical References

• DNA Primers
• IL13RA1 protein, human
• Interleukin-13 Receptor alpha1 Subunit
• Receptors, Interleukin
• Receptors, Interleukin-13

Topics

• Alleles
• Asthma (genetics, immunology)
• Base Sequence
• Case-Control Studies
• Child
• DNA Primers (genetics)
• Female
• Gene Frequency
• Humans
• Interleukin-13 Receptor alpha1 Subunit
• Japan
• Male
• Polymorphism, Genetic
• Polymorphism, Single-Stranded Conformational
• Receptors, Interleukin (genetics)
• Receptors, Interleukin-13