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Suppression of GD1alpha ganglioside-mediated tumor metastasis by liposomalized WHW-peptide.

Abstract
GD1alpha ganglioside-replica peptides were recently isolated from a phage-displayed random pentadecapeptide library by assaying for inhibition of adhesion of RAW117-H10 lymphosarcoma cells to hepatic sinusoidal microvessel endothelial (HSE) cells. We show here that the Trp-His-Trp (WHW) peptide was identified as a minimal sequence of the GD1alpha-replica peptide WHWRHRIPLQLAAGR. The addition of WHW peptide-attached liposomes displayed efficient inhibition of liver metastasis of RAW117-H10 cells as well as of GD1alpha-mediated adhesion of RAW117-H10 cells to HSE cells in vitro. These results suggest that engineered liposomes for peptide delivery are applicable to treatment for metastasis.
AuthorsM Takikawa, H Kikkawa, T Asai, N Yamaguchi, D Ishikawa, M Tanaka, K Ogino, T Taki, N Oku
JournalFEBS letters (FEBS Lett) Vol. 466 Issue 2-3 Pg. 381-4 (Jan 28 2000) ISSN: 0014-5793 [Print] England
PMID10682865 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Drug Carriers
  • GD1alpha-replica peptide
  • Liposomes
  • Peptides
  • Proteins
  • ganglioside GD1alpha
  • G(M1) Ganglioside
Topics
  • Amino Acid Sequence
  • Animals
  • Cell Adhesion (drug effects)
  • Drug Carriers
  • G(M1) Ganglioside (analogs & derivatives, antagonists & inhibitors)
  • Liposomes
  • Liver Neoplasms, Experimental (drug therapy, secondary)
  • Mice
  • Mice, Inbred BALB C
  • Molecular Sequence Data
  • Neoplasm Metastasis
  • Peptides (pharmacology)
  • Proteins (pharmacology)
  • Tumor Cells, Cultured

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