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Effect of intrathecal baclofen on gait control in human hereditary spastic paraparesis.

Abstract
The covariation between thigh, shank and foot elevation angles during locomotion was analysed by means of orthogonal planar regression in a patient with pure hereditary spastic paraparesis before and after an intrathecal bolus of baclofen and in seven healthy subjects. The size, shape and spatial orientation of the loop defining patient's planar covariation (thigh angle vs. shank angle vs. foot angle) significantly differed from the controls' before baclofen, whereas these features resumed normal characteristics after baclofen injection. This shows that alteration of the control of phase coupling for the co-ordination of lower limb segments in human gait by increased spinal reflexes can be reversed by intrathecal baclofen injection.
AuthorsB Dan, E Bouillot, A Bengoetxea, G Cheron
JournalNeuroscience letters (Neurosci Lett) Vol. 280 Issue 3 Pg. 175-8 (Feb 25 2000) ISSN: 0304-3940 [Print] Ireland
PMID10675789 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Muscle Relaxants, Central
  • Baclofen
Topics
  • Adult
  • Baclofen (administration & dosage, pharmacology, therapeutic use)
  • Biomechanical Phenomena
  • Gait (drug effects)
  • Humans
  • Injections, Spinal
  • Locomotion (drug effects)
  • Muscle Relaxants, Central (administration & dosage, pharmacology, therapeutic use)
  • Paraparesis, Spastic (genetics, physiopathology)
  • Reference Values
  • Time Factors

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