In vitro induction of giant cell tumors from cultured hamster islets treated with N-Nitrosobis(2-Oxopropyl)amine.

Abstract

Giant cell carcinoma of the pancreas is a rare tumor. Its histogenesis is still controversial. In a Syrian hamster pancreatic cancer model, tumors similar to human giant cell carcinomas have been induced at an extremely low rate of incidence and after the use of high doses of pancreatic carcinogens. Thus far no tumors of giant cell type have been induced by the in vitro treatment of hamster pancreatic ductal cells with the potent pancreatic carcinogen N-nitrosobis(2-oxopropyl)amine (BOP). In the present study we report the induction of giant cell carcinoma from hamster islets treated with BOP in vitro. The results suggest that in hamsters some component of islet cells, probably stem cells, are the origin of giant cell carcinoma.

• Authors: H Matsuzaki, B M Schmied, A Ulrich, S K Batra, P M Pour
• Journal: The American journal of pathology (Am J Pathol) Vol. 156 Issue 2 Pg. 439-43 (Feb 2000) ISSN: 0002-9440 [Print] United States
• PMID: 10666373 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Carcinogens
• Nitrosamines
• nitrosobis(2-oxopropyl)amine

Topics

• Animals
• Carcinogens (pharmacology)
• Cricetinae
• Culture Techniques
• Female
• Giant Cell Tumors (chemically induced, metabolism, pathology)
• Immunohistochemistry
• Islets of Langerhans (drug effects)
• Male
• Mesocricetus
• Mice
• Mice, Nude
• Microscopy, Electron
• Nitrosamines (pharmacology)
• Pancreatic Neoplasms (chemically induced, metabolism, pathology)
• Time Factors