Loss of dopamine uptake sites and dopamine D2 receptors in striatonigral degeneration.

Abstract

To explore the mechanisms underlying L-dopa response, we studied, by postmortem autoradiography, selective makers of dopamine presynaptic terminals, [3H]WIN 35428, and dopamine D2 receptors, [3H]nemonapride, in the putamen of four Parkinson's disease (PD) and one striatonigral degeneration (SND) neuropathologically confirmed brains as compared with six matched control brains. Dopamine uptake transporter was dramatically decreased (> 90%) both in PD and SND striatum. Dopamine D2 receptors were preserved in PD, but clearly reduced (> 76%) in the SND putamen. These data confirm that L-dopa response is closely associated with the preservation of striatal dopamine D2 receptors.

• Authors: A M González, J Berciano, J Figols, A Pazos, J Pascual
• Journal: Brain research (Brain Res) Vol. 852 Issue 1 Pg. 228-32 (Jan 03 2000) ISSN: 0006-8993 [Print] Netherlands
• PMID: 10661519 (Publication Type: Journal Article)

Chemical References

• Benzamides
• Carrier Proteins
• Dopamine Antagonists
• Dopamine Plasma Membrane Transport Proteins
• Dopamine Uptake Inhibitors
• Membrane Glycoproteins
• Membrane Transport Proteins
• Nerve Tissue Proteins
• Receptors, Dopamine D2
• (1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester
• Cocaine
• nemonapride

Topics

• Aged
• Autoradiography
• Benzamides (metabolism)
• Cadaver
• Carrier Proteins (metabolism)
• Cocaine (analogs & derivatives, metabolism)
• Corpus Striatum (metabolism)
• Dopamine Antagonists (metabolism)
• Dopamine Plasma Membrane Transport Proteins
• Dopamine Uptake Inhibitors (metabolism)
• Female
• Humans
• Male
• Membrane Glycoproteins
• Membrane Transport Proteins
• Middle Aged
• Nerve Tissue Proteins
• Parkinson Disease (metabolism)
• Putamen (metabolism)
• Receptors, Dopamine D2 (metabolism)
• Reference Values
• Striatonigral Degeneration (metabolism, pathology)