Abstract | BACKGROUND: The 21-aminosteroid (U-74389G) is a nonglucocorticoid steroid that was synthesized to inhibit lipid peroxidation without the glucocorticoid activity. We recently demonstrated that the 21-aminosteroid administered to endotoxin shock mice reduces liver injury and improves the survival rate of mice through inhibition of nuclear factor-kappa B activation in the liver. The study was undertaken to determine whether the 21-aminosteroid could suppress pro-inflammatory gene up-regulation through inhibition of nuclear factor-kappa B activation in Kupffer cells. METHODS: RESULTS: CONCLUSIONS:
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Authors | K Okada, S Marubayashi, K Fukuma, K Yamada, K Dohi |
Journal | Surgery
(Surgery)
Vol. 127
Issue 1
Pg. 79-86
(Jan 2000)
ISSN: 0039-6060 [Print] United States |
PMID | 10660762
(Publication Type: Journal Article)
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Chemical References |
- Antioxidants
- I-kappa B Proteins
- Interleukin-6
- Lipopolysaccharides
- NF-kappa B
- Pregnatrienes
- RNA, Messenger
- Tumor Necrosis Factor-alpha
- U 74389F
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Topics |
- Animals
- Antioxidants
(pharmacology)
- Cells, Cultured
- Dose-Response Relationship, Drug
- I-kappa B Proteins
(antagonists & inhibitors, metabolism)
- Interleukin-6
(antagonists & inhibitors, metabolism)
- Kupffer Cells
(drug effects, metabolism, physiology)
- Lipopolysaccharides
(pharmacology)
- Male
- NF-kappa B
(antagonists & inhibitors, physiology)
- Pregnatrienes
(pharmacology)
- RNA, Messenger
(antagonists & inhibitors)
- Rats
- Rats, Wistar
- Shock, Septic
(pathology, physiopathology)
- Tumor Necrosis Factor-alpha
(antagonists & inhibitors, genetics, metabolism)
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